Sentence examples for molecules aimed at targeting from inspiring English sources

The importance of PI3K in the fundamental processes that lead to tumourigenesis has prompted the development of small membrane permeable molecules aimed at targeting components of the PI3K pathway for therapeutic intervention against cancer.

She was also a project leader in the NCI Cancer Target Discovery and Development Center at the Broad Institute aimed at targeting causal cancer genes with small molecules.

These schemes are aimed at targeting that backbone.

Therefore other therapies aimed at targeting LLPCs are needed.

Structure-based drug design against heterogeneous targets requires a departure from the classic 'lock-and-key' paradigm that leads to the development of conformationally constrained molecules aimed at a single target.

Another approach using [F]FDG and [F]FDR for oxime formation with target molecules aimed at the synthesis of cannabinoid ligands for PET imaging of the cannabinoid receptors 1 (CB1) and 2 (CB2) [ 38].

Given the prevalence of human T-ALL cases coexpressing SCL and LMO2, this interface emerges as a promising target for the development of small molecules aimed at disrupting protein:protein interactions.

It aims at targeting interpersonal problems that maintain psychopathology [ 67].

Currently, there exist several new molecules for the treatment of RA, aimed at different targets.

These proteins are key regulators of the bacterial cell cycle [58] and may be targets for small-molecule inhibitors aimed at perturbing growth and/or replication of 'Ca .L. solanacearum'.

Most CFTR-ΔF protein regulators have been characterized using RNAi methods aimed at identifying targets for increasing CFTR-ΔF processing by small molecule inhibitors [ 15, 16].