Sentence examples for molecules aimed at from inspiring English sources

Structure-based drug design against heterogeneous targets requires a departure from the classic 'lock-and-key' paradigm that leads to the development of conformationally constrained molecules aimed at a single target.

As recently reported [ 39], one of the current therapeutic strategies in FRDA disease is the development of molecules aimed at increasing frataxin expression.

Moreover, as pulmonary artery smooth muscle cells from familial PAH patients demonstrate increased sensitivity to TGFβ signalling, molecules aimed at blocking this pro-proliferative transduction system may be of therapeutic utility (Morrell et al., 2001).

Given the prevalence of human T-ALL cases coexpressing SCL and LMO2, this interface emerges as a promising target for the development of small molecules aimed at disrupting protein:protein interactions.

Another approach using [F]FDG and [F]FDR for oxime formation with target molecules aimed at the synthesis of cannabinoid ligands for PET imaging of the cannabinoid receptors 1 (CB1) and 2 (CB2) [ 38].

The importance of PI3K in the fundamental processes that lead to tumourigenesis has prompted the development of small membrane permeable molecules aimed at targeting components of the PI3K pathway for therapeutic intervention against cancer.

More specifically, since few interactions were modelized for the quinoline moiety (part A, Figure 1), we began by modifying this part of the molecule aiming at improving the affinity of the compounds for the deoxycytidine binding pocket of DNMTs.

Bioactive surfaces refer to surfaces with immobilized bioactive molecules aimed specifically at promoting or supporting particular interactions.

Rather than inferring the structure from the tracking of single molecules, we aimed at reconstructing the structure itself, meaning that we tried to visualize the sub-spine actin organization.

Emerging and future work is expected to include advances in single-molecule techniques aimed at such investigations, and increasing work on more complex systems from both the physics and biology standpoints, including folding and dynamics of systems of interacting proteins and of proteins in cells and organisms.

This new "Arctic molecule" is aimed at protecting humans from oxidative stress.