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Synthetic small organic molecules Imidazoquinoline (@Aldara), C48/80, Vitamin E TPGS*, α-GalCer** Different molecules activate the immune response through various mechanisms, induce systemic and mucosal immunity.
However, it is still largely unknown how small molecules activate the endogenous gene regulation network, and gradually enable cell fate transitions.
Many oncogenic signaling molecules activate the MAPK/ERK pathway [35].
In addition, the molecules activate the olfactory system connected to the limbic system via binding to olfactory receptors.
After forming adducts with DNA, the cisplatin molecules activate the endoplasmic reticulum (ER) stress pathway (also known as the unfolded protein response), thereby activating apoptotic caspases [8].
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In addition to their well known role in energy generation and storage, FAs can be potent signaling molecules, activating the nuclear hormone receptors peroxisome proliferators-activated receptors (Pars).
A possible additional effect induced by circulatory molecules activating the system cannot be excluded, but this activation was not accompanied by an inflammatory response, as discussed above for the cytokines.
PTX3 is released by mononuclear phagocytes, neutrophils, epithelial and endothelial cells in response to inflammatory signals; PTX3 recognizes microbial molecules, activates the classical pathway of complement and facilitates recognition by macrophages and dendritic cells.
SAR requires signal molecules activating the expression of pathogenesis-related (PR) genes and salicylic acid (SA), jasmonic acid (JA) and ethylene (ET) are involved in regulating their expression.
Activation of TLR induces various molecules activating the immune response (Takeda et al, 2003; Akira and Takeda, 2004; Li et al, 2009).
Simultaneous binding of n product molecules activates the enzyme which allows for subsequent substrate binding and conversion into product with specific rate k.
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