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However, classical bispecific molecules activate only a single class of immune effector cell that may not yield optimal immune responses.
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Because of their high amino acid sequence similarity, designing small molecules that selectively activate only 1 receptor among the 3 subtypes is difficult.
The cAMP molecules activate other enzymes that, in turn, activate ion channels.
Resveratrol activates sirtuins, and some similar molecules activate them much more.
Many oncogenic signaling molecules activate the MAPK/ERK pathway [35].
These molecules activate and regulate dermal repair processes.
These constructions include bispecific CAR-T cells, which can be activated only by the identification of both CAR molecules (Wilkie et al., 2012), and the synNotch circuit, in which T cells are armed only by a synthetic Notch receptor activated by one target to induce the expression of a CAR against another target (Roybal et al., 2016).
Future applications could include the use of other types of fluorescent probes, in particular, those that are activated only after interaction with the target for the monitoring of a variety of tumor-related molecules [8].
can be activated only on small nanoparticles or roughened Au(1 1 1) surfaces, whereas Au(1 1 1) single crystals or extended metal films are active in the reaction of large molecules.
The match is activated only after both parties agree.
Higuchi, H. & Yanagida, T. Force generation and detachment of single kinesin molecules activated by laser photolysis of caged ATP and ADP.
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