siRNAs are very potent drug molecules, able to silence genes involved in pathologies development.
These cells secrete inflammatory molecules able to interact with proteins of ECM like collagens, laminins, elastin, and tenacins.
Bioscavengers are molecules able to neutralize neurotoxic organophosphorus compounds (OP) before they can reach their biological target.
The molecules able to satisfy the pharmacophore have been submitted to a docking phase to filter molecules with a high propensity to interact with HDAC7 enzyme.
Inhibitory strategies have focused on antisense molecules, inhibitors of reverse transcriptases, and small molecules able to interact with and stabilise four-stranded (G-quadruplex) structures formed by telomeres.
Here we perform a high-throughput screen, combined with nested counterscreens to identify small molecules able to inhibit the Impα/β1 CP interaction for the first time.
The present result shows that molecules able to control the charge recombination in DSSCs would be structures of interest in the design of highly efficient phenothiazine dyes.
There are several key features shared by novel anti-HSV drugs, from currently available optimized drugs to small molecules able to interfere with various virus replication steps.
Based on the crystal dimeric structure of HLA-DR molecules, we designed, and synthesized molecules able to induce the putative coreceptors dimerization.
The identification of molecules able to interact with the replication complex and inhibit its activity is a promising strategy for the design of new anti-orthopoxvirus drugs.
The design of molecules able to target the amyloid pathology in tissue is receiving increasing attention, both for diagnostic and for therapeutic purposes.
