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However, the high degree of homology between related glycosyltransferases makes discrimination between these enzymes with specific small molecules a challenge.
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With regard to the cardinality of groups within a molecule, a challenge that is absolutely key to machine-based classification in chemistry is scalar implicature.
From an analytical perspective, CGA molecules offer a challenge owing to the structural similarities and complexity of these compounds.
Since highly symmetric molecules impose a challenge for substructure search algorithms, we test a phenylring query against a fulleren target as a worst-case search scenario.
The development of a practical approach determinining the absolute configuration of natural and artificial molecules is a challenge in the life and material sciences fields.
Engineering proteins to bind small molecules presents a challenge as daunting as drug discovery, for both hinge upon our understanding of receptor ligand molecular recognition.
Synthetic riboswitches are engineered to regulate gene expression in response to a variety of non-endogenous small molecules, and a challenge to select this engineered response requires robust screening tools.
Specific and direct tracers for the molecular imaging of fibrosis, especially collagen-targeting molecules, constitute a challenge and a potentially wide field of interest for imaging methods, including radionucleide imaging and MRI [9].
While the ability to identify specific targets and define mechanisms of action for all of these small molecules remains a challenge, improved methods and reagents are continually evolving to address this aspect of phenotypic screening.
He originated and leads the 'Dial-a-Molecule' Grand Challenge (www.dial-a-molecule.org), which has the 20 40 years aim of making the synthesis of new molecules as quick and easy as it currently is to order a commercial compound.
The small molecules detection remains a challenge for diagnostics.
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