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In contrast, continuous conformational change within a molecule would lead to an almost infinite number of classes.
Given the relative expression patterns of CB2R (predominantly peripheral tissue) and CB1R (predominantly CNS) it was also antipated that aiming for a peripherally restricted molecule would lead to improved in vivo efficacy and reduced side-effects.
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Therefore, we investigated whether the DSB-mimicking Dbait molecules would lead to H2AX phosphorylation in cells.
Therefore, identification of such signaling molecules would lead to the development of therapeutic interventions to specifically target them.
Accordingly, these transitions of regulatory molecules would lead to transitions in the cytoskeletal movements necessary for macropinosome closure.
In a covalently closed circular molecule, this would lead to compensatory induction of positive superhelical turns.
There are two possible reasons that may lead to the apparent discrepancy: 1) It was not clear how many Pif1 monomers were loaded per DNA molecule in Ramanagoudr-Bhojappa et al., and in fact it is quite likely that more than one Pif1 monomers were loaded per DNA molecule which would lead to efficient unwinding of DNA-DNA duplexes.
For isolated single molecules this would lead to a magnetic interaction energy given by Δ E=Δ χB0/2 μ0 where Δ χ is the susceptibility anisotropy.
Moreover, the discovery of molecular pathways altered in cancer progression, as well as the identification of molecule-susceptible targets, would lead to the development of novel alternative therapies.
In addition, non-competitive VHHs targeting the same tumour marker could be combined as simultaneous binding of different VHHs to the same target molecule would likely lead to even better T/B ratios and consequently to an improved tumour detection.
Apparently, the NE is that each transmitter uses the highest molecule emission power, which would lead to low system efficiency compared with the centralized scheme.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com