Therefore, when employing neutral species, the improvement was bigger for the large and flexible molecules with several charged groups.
DNA-intercalating drugs are planar molecules with several fused aromatic rings that form stacks between DNA base pairs, reducing the opening and unwinding of the double helix.
This stems from the observation that often the generic idea of chemical similarity is strongly influenced by small differences in the number and type of heteroatoms, i.e. molecules with several similar features (molecular weight, number and type of rings, bonds etc).
The first are linear flexible terpenoid or terpenoid-related molecules with several freely rotable bonds that include also natural JH-I, JH-II and JH-III (Class I structures 1 3).
The stereocontrolled formation of such complex molecules with several adjacent stereogenic centers is regarded as a great challenge, because with an increase of the stereocenters the number of possible stereoisomers also increases exponentially.
B-cell activation is regulated by molecules with several distinct modes of action: A first example, the adapter molecule Bam32 (B-lymphocyte adapter of 32 kDa), helps promote BCR-induced cell cycle entry, while the secondary messenger superoxide has the opposite effect.
Our method is broadly applicable for the prediction of protein-small molecule interactions with several novel applications to biological research and drug development.
The second network has the MYH6 as a key molecule connected with several direct significant relationships to the other genes that are enriched for significantly associated SNPs (Fig. 8).
The CDH2 gene encodes a cell-cell adhesion molecule (32) with several functions, including establishment of embryonic left-right asymmetry (33), synaptic adhesion (34), and dendritic spine (35) and cortical morphology (36).
RNA molecules associate with several extracellular carriers, including lipoproteins [ 31] and protein complexes [ 32– 34], but extracellular vesicles (EV, encompassing the various definitions of exosome, microvesicle, etc).
