Many studies have also shown that ROS are the major signaling molecule which mediates microglial activation induced by inflammatory mediators, including LPS [ 71].
Integrin αvβ3 is a molecule which mediates the migration of endothelial cells through the basement membrane during blood vessel formation.
The WT G-CSFR contains an STQPLL dileucine motif in its cytoplasmic domain at aa. 749 754 which is identical to the dileucine motif in the cytoplasmic domain of the homologous gp130 molecule which mediates IL-6 internalization and down-modulation of the IL-6R [23], [23].
Endostatin is an important inhibitory molecule which mediates the sequential steps involved in angiogenesis.
These differ from our data that ITLN is a functional signaling molecule which mediates the virulence effect of VvpE to repress Muc2 expression.
VCAM1 encodes vascular cell adhesion molecule, which mediates leukocyte-endothelial cell adhesion and signal transduction in order to enhance inflammation in cervical tissue [ 30].
Similar to Shp2, Shc is an intermediate molecule which mediates the assembly of FGFR and Grb2-SOS complexes, also to activate the Ras/Raf/MEK/MAPK pathway [ 3, 41, 44].
