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Here we investigate an alternative active-site design in which the catalytic water molecule was replaced by the side chain of a glutamic acid.
In experiments where the difunctional bisimide (isophthaloyl-bis-caprolactam), which has two acyllactam groups per molecule, was replaced on a molar basis by the monofunctional N-acetylcaprolactam, which has one acyllactam group per molecule, the polymerization rate was slower by about 50% because the concentration of the acyllactam group was reduced by half.
We previously generated a type A virus possessing a chimeric HA in which the entire ectodomain of the type A HA molecule was replaced with that of the type B HA, and showed that this virus protected mice from challenge by a wild-type B virus.
Then, the crystalized RU486 molecule was replaced for the optimized RU486 structure by superimposing the corresponding carbon atoms of the C ring.
In the case of nilotinib, a N-methylpiperazine ring that participated in hydrogen bonding with Ile360 and His361 in the imatinib molecule was replaced.
The sensitivity of the test for antibodies in RA was increased from 24%to88%8% when the intact CII molecule was replaced by CB10 and, notably, this was not at the expense of specificity, which was 94% when CB10 was used.
Similar(54)
In sucralose, three of the hydrogen-oxygen groups in each sugar molecule are replaced with chlorine atoms.
The reaction is usually one in which an atom or a group of atoms in the molecule is replaced by another atom or group.
In a substitution reaction, an atom or group of atoms in a molecule is replaced by another atom or group of atoms.
In an alcohol one hydrogen atom of a water molecule is replaced by an alkyl group, whereas in an ether both hydrogen atoms are replaced by alkyl or aryl groups.
Substitution reaction, any of a class of chemical reactions in which an atom, ion, or group of atoms or ions in a molecule is replaced by another atom, ion, or group.
Related(20)
drug was replaced
compound was replaced
molecule was substituted
dna was replaced
formula was replaced
membership was replaced
element was replaced
wing was replaced
analysis was replaced
chemical was replaced
molecule was studied
molecule was suggested
molecule was cleaved
molecule was carried
molecule was produced
molecule was used
molecule was limited
molecule was improved
molecule was fulfilled
molecule was inserted
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com