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In the d4-iPF4α-VI design, the deuterated part of the molecule was introduced last in the synthesis.
In this model, two chemical equilibria (H3PO4 ⇌ H+ + H2PO4−, and H2PO4− + H3PO4 ⇌ H5P2O8) were taken into account and an ionic-strength dependence of the second virial coefficient for the interaction between ion and undissociated phosphoric acid molecule was introduced.
The RU486 molecule was introduced similarly to the GR LBD-RU486 complex described below.
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They can also synthesize oligomers when an acceptor molecule is introduced into the medium.
Unlike oral treatment, the complete HA molecule is introduced to the synovial fluid of the affected joint, providing a variety of different mechanisms for symptom relief [33].
When the RU486 molecule is introduced in this way in the GR-LDB, 11-substituent diethyl amino group atoms and Leu753 (H12) side chain atoms overlap giving rise to sterical clashes (Figure S3B).
When the RU486 molecule is introduced in silico into the GR LDB, atoms from the 11-substituent diethyl amino group and Leu753 (H12) side chain atoms overlap (see "Materials and Methods" and Figure S3B).
However, the retail cost of the NPRx is expected to drop once generic versions of this molecule are introduced following the expiration of the NPRx's patent.
These costing parameters are generally modeled as fixed-in-time parameters which are based on the cost of each drug at the time of model conception. 1 However, such an assumption does not truly reflect reality, as the cost of a patented drug drops once generic versions of the molecule are introduced.
Each plasmid expressing the affibody molecules was introduced into MH7A cells to observe any inhibition of IL-6 production.
A recent and alternative way of quantifying non-covalent interactions (NCIs) between molecules was introduced by Johnson et al. [60] and Contreras-García et al. [61].
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