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Because of its unique structure, Oleosin serves as an interfacial molecule to stabilize the oil droplets within the hydrophilic cytosol.
Without knowing whether a molecule can grip conformation 2 by binding atop the phenolic ring of Tyr80, we initially wanted to design a clip-like molecule to stabilize conformation 2 using two functional groups simultaneously binding on both sides of the phenolic ring.
(13) In pancreatic cancer, galectin-4 acts at an adhesion molecule to stabilize cell cell contact and inhibits metastasis formation through preventing the release of tumor cells.
Studies of L55P, pretreated with diflunisal, demonstrated the capacity of the small molecule to stabilize tetrameric TTR and inhibit fibril formation as shown by the absence of observable Congo red binding.
11 In this assay the ability of a molecule to stabilize the protein during its thermal unfolding is quantified by its thermal shift (Δ Tm): the difference in the protein unfolding temperature in the presence and absence of a ligand.
As an idea for designing inhibitors that would not target the active site, Perkins et al. proposed that the delicately balanced FF ↔ LU equilibrium could be shifted by a small molecule to stabilize a single conformation (either the FF or the LU), thereby preventing the structural changes required for Prx catalysis.
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The results indicate the feasibility of using solvent molecules to stabilize the floppy CH5+ ion in order to make it amenable to spectroscopic study.
Modified silica NPs are used as emulsifiers besides the commonly used surfactant molecules to stabilize an emulsion system by preventing the coalescence of droplets.
Based on the experimental and theoretical results, it suggests that the intercalation of glucose in NiMn LDH could be an effective approach to enhance electrochemical performance, of which it also could be generalized to intercalation of other molecules to stabilize the α-phase of LDH.
These water molecules in turn recruit and interact with other residues and more water molecules to stabilize product binding.
They are highly reactive and have a tendency to interact with neighboring molecules to stabilize their structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com