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Furthermore, for a low affinity -bound small molecule to recognize multi-targets, the structural similarity at the active core of the target sites also plays a crucial role.
TLR4 is located mainly in the plasma membrane and associates with the LPS binding protein CD14 and myeloid differentiation- (MD -2 MD -2ule to recognize LPS.
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Biosensors employ biological molecules to recognize the target and utilize output elements which can translate the biorecognition event into electrical, optical or mass-sensitive signals to determine the quantities of the target.
Poliovirus is structurally similar to other human enteroviruses (coxsackieviruses, echoviruses, and rhinoviruses), which also use immunoglobulin-like molecules to recognize and enter host cells.
The bacterial protein, Cas9, has the potential to enable a simpler approach to genome engineering because it is a DNA-cleaving enzyme that can be programmed with short RNA molecules to recognize specific DNA sequences, thus dispensing with the need to engineer a new protein for each new DNA target sequence.
A molecule able to recognize cardiomyocytes would have significant value in diagnosis and treatment.
While further research is needed to define its function, our data indicate that MgC1q is a pattern recognition molecule able to recognize pathogens during innate immune responses in Myitilus galloprovincialis.
Thus, the "AND-gate" CAR T cells have a combinatorial antigen recognition circuit working in a sequential manner: the constitutively expressed synthetic Notch (synNotch) receptor first binds with antigen B and then induces CAR molecule expression to recognize antigen A (Fig. 2B).
One of these genes (Spon2) is a pathogen-associated molecular pattern recognition molecule known to recognize Escherichia coli lipopolysaccharide and numerous gram negative bacteria [31].
Hence, we analyzed whether α-MSH also affects the MHC class I expression in purified CD8+ T cells, a molecule needed to recognize and respond to relevant tumor-antigens.
He worked on the organic synthesis of molecules able to recognize and bind with other, smaller molecules, a phenomenon called molecular recognition, which had won Donald J. Cram, Jean-Marie Lehn, and Charles J. Pedersen the Nobel Prize in chemistry in 1987.
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