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Secondly, we investigated the targeting and imaging properties of a dimerized minigastrin, where a spacer of three neutral d-glutamines preceded each minigastrin molecule to gain further insight into the influence of multimerization and spacer lengths on affinity, specificity and stability.
One example is imatinib mesylate (Gleevec, formerly STI571), which was the first mechanism-based drug targeting an oncogenic molecule to gain FDA approval.
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At higher temperatures, however, the coatings open or release from the surfaces, giving the opportunity for oxygen molecules to gain access to the Cu cores.
Systematic density functional theory (DFT) calculations have been performed on the molecules to gain insights into the structural, electronic and optical properties.
In fact Mtb utilizes such cell surface molecules to gain access into macrophages.
We expected that the tandem repeats could obtain stronger activity through elongating the half-life of T α1 and simulating polymerization of monomer molecules and thereafter triggering the polymerization and activation of receptors which was usually used by molecules to gain function.
The trans/cis-isomerization of TBA is accompanied by reversible changes in the geometrical and electronic structure of the molecules, allowing to gain mechanistic and quantitative insight into the switching process.
The advantages of using biochemical QIBs over morphological in the assessment of cytostatic molecules continues to gain acceptance [ 6], including patient stratification and prognostic impact before therapy is initiated [ 7].
This large interface causes a conflict in the design and optimization of medically useful BoNTA endopeptidase inhibitors in that, on the one hand, a large molecule is needed to gain more interactions at the unusually large interface, and on the other hand, a small molecule is required to ensure good cell permeability.
Structure-based design strategies were applied to significantly improve enzyme potency and the polarity of the molecule was adjusted to gain cellular activity.
However, in literature, gold-based nanosensor has to be integrated with specific "ligand" molecule in order to gain molecular recognition ability.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com