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One of the new compounds (1) exhibited similar potency as the reference compounds, confirming that a thiazepinedione fused to a naphthalene ring system is the best combination for the molecule to accommodate into the IN active site.
Irrespective of the specific explanation (s), it would seem clear that helices 6-9 provide a ribosome-stabilized fulcrum, which allows movements within the remaining portion of the molecule to accommodate the nascent chain.
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This is explained by a connectivity term which expresses the difficulty of high connectivity structures (like lamellar arrangements or microdomains "anchored" by triblock molecules) to accommodate deformation without significant irreversible distortions (i.e. orientation).
Segments of chromosomal DNA are highly dynamic in vivo (Fiebig et al., 2006), with the expectation that the movement is larger when a locus is being segregated after replication, when the cell has to reorganize the remaining part of the parental molecule and to accommodate the newly synthesized molecules.
The FLIM images evidenced that porphyrin aggregates were radially distributed, and that the most aggregated porphyrin molecules tended to accommodate in the inner part of the porphyrin ring, while the monomers were preferentially located in the outer part of the ring.
Typical DNA adsorption studies that report high levels of single-stranded adsorption utilize citrate-capped AuNPs where the citrate molecule is displaced to accommodate DNA laying down on the surface.
This limited space, therefore, does not allow the putative catalytic water molecule to be accommodated in that site as it would have serious short contacts, and hence no deacylation.
Small molecules will need to accommodate these interactions to activate PKG consistent with this idea, cAMP does not stabilize the same interactions as cGMP and can only weakly activate PKG.
Therefore, during invagination the Sla2 molecules would reorient to accommodate membrane bending and the center of mass positions of their N and C-termini would move closer to each other.
NVT and NPT equilibration runs were performed for 500 ps each, during which solvent molecules were able to accommodate around the protein that was fixed in space through the application of a 1,000 kJ · mol−1 · nm−2 force constant on each protein's Cα atom.
The structure of NLC is irregular and has defects in the packing of molecules which offers maximum space to accommodate drug molecules resulting in high drug loading capability (Li et al. 2010).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com