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Injection of pax6.1 mRNA resulted in an increase in cad4 expression, whereas overexpression of sonic hedgehog (shh), a midline signaling molecule that reduces pax6.1 expression, caused a reduction in cad4 expression throughout the brain.
For example, any molecule that reduces CAF heterogeneity but promotes homogeneity would be predicted to inhibit CAF pro-tumorigenic activity.
The multimers have mutations in the alpha-3 domain of the major histocompatibilty complex (MHC) molecule that reduces binding to CD8 molecules.
Stavudine, an antioxidant molecule that reduces ROS production and enhances mitochondrial function, can also increase muscle insulin sensitivity in humans [ 259].
There is no significant difference between Zn2+-depleted Zn2+-depletedreated neurons in triple-transfected cells, indicating that Shank1 is a key PSD maturation molecule that reduces the Znnc sensitivity of immandre synapses.
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The fluid includes surfactant molecules that reduce the surface tension of the water, making the foam.
Foamability is linked with flexible protein molecules that reduce the surface tension which keeps air bubbles in suspension and slows down the rate of coalescence.
Development of small molecules that reduce the expression of etiologically relevant toxic proteins is a strategy that may also be extended to familial ALS linked to gain of function mutations in other genes.
The recent introduction in the clinical practice of synthetic TTR-stabilizing molecules that reduce protein aggregation provides the rationale to search natural effective molecules able to interfere with TTR amyloid aggregation by hindering the appearance of toxic species or by favoring the growth of harmless aggregates.
Enzyme inhibitors are molecules that reduce or abolish enzyme activity, while enzyme activators are molecules that increase the catalytic rate of enzymes.
Pifithrins- α and - μ (reviewed in Gudkov and Komarova) are two examples of small molecules that reduce p53 activity.
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