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Amylose typically makes up 25 30% of the starch granule, it is an essentially linear molecule that possesses an α-1,4 linkage backbone structure but can be sparsely branched by α-1,6 linkages.
ChM1 is the first example of an endogenous molecule that possesses two different anti-tumor actions.
In this regard, we have recently reported the identification and characterization of a small molecule that possesses both of these properties.
Andrographolide (AND) is a diterpenoid lactone molecule that possesses various biological activities, including anti-inflammatory [ 6], immunomodulatory [ 7], hepatoprotective [ 8], antiviral [ 9], and antitumoral effects [ 10].
However, IC7-1 is a neutral molecule that possesses both a quaternary ammonium ion in the core cyanine moiety and a carboxyl group on the side chain.
Our study as presented here identifies INZ as a novel small molecule that possesses an ability to induce p53 level and activity, consequently leading to p53-dependent apoptosis.
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The inverse-QSAR problem seeks to find a new molecular descriptor from which one can recover the structure of a molecule that possess a desired activity or property.
This limitation can be overcome for molecules that possess permanent magnetic moments or electric dipole moments by using external magnetic or electric fields to bring the energy spacing between levels into coincidence with the frequency of the laser.
An analogous method, called Stark spectroscopy, involves the use of a strong variable electric field to split and vary the spacing of the energy levels of molecules that possess a permanent electric dipole moment.
The purpose of this study was to identify new small molecules that possess activity on human toll-like receptor 4 associated with the myeloid differentiation protein 2 (hTLR4/MD2).
Although the majority of the initial G-quadruplex studies were performed on DNA molecules, there currently exists a rapidly growing interest in the investigation of those formed in RNA molecules that possess high potential of acting as gene expression regulatory elements.
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