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Proteolytic and spectroscopic analyses of tropomyosin have established that the central region of the molecule that includes P4 and P5, residues ∼130 190, is locally unstable and at least partially unfolded at physiological temperature [37] [39].
The half of the molecule that includes the A1-B1 subdomands and the active site is more conserved structurally.
To rigorously examine these possibilities, we tested a truncated dynein molecule that includes its native dimerization domain, but lacks any of its associated subunits.
A patch of LIC1/2-specific acidic residues (including E325, E304, and D306) lie on the opposite side of the molecule that includes the C-terminal loops and α-helix 4, 4a, and 6.
In all organisms examined, the 18S genes are the first of the ribosomal RNAs to be synthesized when Polymerase I initiates transcription at a promoter located at the end of the Non Transcribed Spacer (NTS, also called intergenic Spacer - IGS) of the rDNA repeat unit, giving rise to a large precursor RNA molecule that includes all rRNA species.
Importantly, our molecular evolution analyses work suggest novel research questions regarding the "functional homology" between the New World monkeys RLN and the RLN1 and RLN2 genes from apes, and of the putative functional role of the C peptide, and the prorelaxin (i.e., the relaxin molecule that includes the C peptide).
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This is one of the lines of evidence that has led them to the conclusion that, in addition to its role in storing energy as a hedge against future famine, getting fat is a protective mechanism against metabolic syndrome.Their thesis is that lipids (the group of molecules that includes fats), which are needed in small amounts to make cell membranes, are toxic in larger quantities.
And up to 30% of people around the world may have a lesser known but related metabolic illness, NAFLD, in which lipids the family of molecules that includes fats amass in the liver.
While the bulk of CureVac's prize money will go to basic molecular immunology research, Hoerr says he also wants to set aside a portion to pay tribute to Miescher, the biologist from Switzerland who identified nucleic acids, a family of key biological molecules that includes DNA and RNA, in his lab in Tübingen.
Vitamin A is a family of molecules that includes retinol and potent bioactive retinol metabolites that are required for health.
CD44 is a separate family of cell adhesion molecules that includes the standard (CD44s) and variant isoforms, which are products of alternative splicing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com