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This disorder is due to deficiencies in von Willebrand factor (vWF), a molecule that facilitates platelet adhesion and is a plasma carrier for factor VIII. Symptoms usually include abnormal bruising, bleeding from mucosal surfaces such as the gums and the gastrointestinal tract, and prolonged bleeding from any break in the skin or during surgery.
Shortly thereafter, Robert W. Holley determined the structure of transfer RNA (tRNA), the adapter molecule that facilitates the process of translating RNA into protein.
Most of these systems involve covalent conjugation of PNA to another molecule that facilitates delivery into a cell, such as a lipid or cell-penetrating peptide [22], [25] [30].
ICAM-1 is an adhesion molecule that facilitates trafficking of neutrophils to the lung and is upregulated on the lung endothelial surface during ALI/ARDS [ 2].
We found that RASSF1A is a key adaptor molecule that facilitates the recruitment of TRAF2 and TRADD to the TNFR1 upon TNF-α stimulation, and this process is important in the regulation of downstream signal transmission.
As a ligand of p-selectin, CD24 serves as an adhesion molecule that facilitates the metastatic process by supporting the rolling of cancer cells on activated platelets and endothelial cells [ 11, 12].
Similar(53)
Although MoDC differentiation is accompanied by an increased expression of several surface molecules that facilitates T cell stimulation, the regulation of MHC class II molecule transport plays a central role in developmentally restricting antigen presentation [42], [43].
These contain opsins, which are molecules that facilitate the generation of electrical signals in response to light absorption.
Silk surfaces offer active sites that aid the mineralization and/or bonding of bioactive molecules that facilitate bone regeneration.
Cyclin-dependent kinases (Cdks) are molecules that facilitate the progression of the cell cycle by binding to cyclins and phosphorylating downstream proteins that assist in cell cycle propagation.
Finally, we envision that ExMVs-producing cell lines could be enriched for molecules that facilitate their tropism to the damaged organ and subsequently promote retention of ExMVs in the damaged tissues (Fig. 2d).
Related(20)
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Justyna Jupowicz-Kozak
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