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For instance, a molecule that drives a particular form of cancer could make a good target for treating the disease.
TGF β-3 is also an important stimulatory molecule that drives chondrogenesis by activating the Smad signalling pathway.
Mutation of PTEN can destabilise hypoxia-inducible transcription factor 1 (HIF-1), the molecule that drives VEGF transcription.
Generation of the mixed phosphosulfate anhydride bond in APS yields a high-energy molecule that drives subsequent reduction reactions in the assimilatory pathway [ 8– 11].
A glutamine residue in the Ras protein helps to properly orient an active site water molecule that drives the hydrolysis of GTP to GDP.
Theoretically, drug-induced adverse events (AEs) are avoidable while maintaining anti-tumor effects by targeting the critical molecule that drives proliferation of and is solely present in cancer cells.
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It is the combined weight of influence of these molecules that drives the gross anatomical change in fibre composition.
The work, published today in Science Translational Medicine, reflects a shift in the field, from examining hookworms' immune effects to identifying the molecules that drive them.
The rationale for using ECM as a natural biomaterial is the presence of bioactive molecules that drive tissue homeostasis and regeneration.
These mechanisms are mediated by aberrantly activated signaling molecules that drive the fibrotic process, such as TGF-β, IGF, PDGF, or TNF-α [9], [20].
DOI: http://dx.doi.org/10.7554/eLife.07777.001 DNA contains instructions to make all the proteins and other molecules that drive essential processes in cells.
Related(20)
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Justyna Jupowicz-Kozak
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