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Owing to the characteristics of PPI targets, the small molecule term is a generic name to refer to synthetic molecules and small peptides that bind to these interfaces.
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We used structure-based design to develop a nonpeptide, cell-permeable, small molecule, termed as LLL12, which targets STAT3.
We postulate an existence of a novel molecule termed 'double amino acid' containing four functional groups connected to one C atom ((NH2 2C COOH 2).
The result is a joint molecule termed a displacement loop (D-loop).
Using a structure based computer design our collaborators designed a non-peptide small molecule, termed LLL12 (Figure S1).
We previously characterized a novel molecule termed synoviolin, which is strongly expressed in rheumatoid synovial fibroblasts and contributes to the pathogenesis of rheumatoid arthritis (RA) [11] [16].
A 550 600 bp subset of the rbcL molecule (termed rbcL-a) located at the 5' end of the large subunit that exhibited maximal sequence variation and universal amplification was also included in the analysis.
A fraction containing a small (<1 kDa) heat-stable and water soluble anti-inflammatory <span class="lh">molecule, termed Saccharomyces anti-inflammatory factor (SAIF), has been identified in the yeast supernatant [30].
It would seem that mazEF-mediated cell death is a population-dependent phenomenon requiring a quorum sensing molecule, termed extracellular death factor, which is a linear pentapeptide (NNWNN) important for mazEF-mediating killing activity [20].
In contrast, adaptive immunity involves the generation of immune responses specific for a particular molecule, termed an antigen.
Human AM is a 52-amino-acid peptide which is synthesized as part of a larger precursor molecule termed preproadrenomedullin.
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