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Here, we identified ninein, a downstream molecule regulated by Pax6, that is a centrosomal protein crucial for INM regulation, which is a cellular feature of APs.
SIRT3 is an antiaging molecule regulated by calorie restriction and mitochondria-localized NAD+-dependent deacetylase.
The Nef protein--or possibly another molecule regulated by Nef--may allow HIV to get a better foothold in the body, Sattentau says, by decreasing MHC levels and thus protecting infected cells long enough for the virus to replicate and infect new cells.
Next we examined the expression of p21, which is the downstream molecule regulated by p53.
Overexpression of PTEN also correlates with decreased total levels and nuclear localisation of cyclin D1, a key cell cycle molecule regulated by PKB/Akt.
Since HIF-1α is the key molecule regulated by tumour hypoxia, HIF-1α deregulation in tumour cells may confer resistance in these cells [ 17, 18].
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Different molecular cues function through diverse mechanisms including concentration gradient, area specific or cell type specific expression, repellent or attractive ligand and receptors, and molecules regulated by neuronal activities.
Some of the very upstream molecules regulated by Wnts have been identified.
Relative mRNA expression of ECM molecules regulated by DDR2 expression in DDR2+/+ and DDR2-/ skin fibroblasts.
These results suggest that poFUT1 is one of the target molecules regulated by LIF.
Repression of E-cadherin and other epithelial markers by HNF1α could also go through other molecules regulated by HNF1α.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com