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Here we show that mutSOD1 converts Bcl-2 into a toxic molecule, making it an active accomplice of its own toxicity.
The protein moiety of most glycoproteins is the functional part, while the carbohydrate moiety contributes to the attainment of an adequate tertiary structure and modifies the glycoprotein molecule making it more resistant to degradation, and facilitates its secretion (7).
In addition, the SPR signal is proportional to the mass of the molecule, so its sensitivity diminishes with the size of the molecule, making it extremely challenging to detect small molecules.
Natural gas contains only one carbon and four hydrogen atoms per molecule, making it the cleanest of fossil fuels.
Connection tables store information on the atoms, bonds and, optionally, the atoms' coordinates for a given molecule, making it a graph representation of a molecule [17, 18].
Region II (red in Figure 4C and 4D) is on the surface of the molecule making it accessible to a drug, however, it is relatively isolated from the catalytic domain and is not involved in any functional interactions.
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The lack of antibodies that specifically recognize extended-C/EBPα and the impossibility to specifically target the endogenous protein by knockdown strategies (all protein isoforms can be translated from a single mRNA molecule) makes it technically difficult to address its physiological functions and sites of action in depth.
Fragmentation of the substrate followed by atom mapping onto the product molecule makes it possible to identify the nucleophilic atom in an automated manner (Figure 2).
The absence of resonance structures in the NO2- molecule makes it easier to reduce than NO3- [58], which is reflected in reduction reaction rates.
More importantly, the switching of crosslinking strategy in the same molecule makes it possible to fabricate microgels with almost the same composition but variable gelation time and elasticity.
Besides, the presence of multiple acid and hydroxyl groups in the HA molecule makes it an ideal candidate for chemical modification.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com