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Intercalation is a special binding mode where the planar aromatic moiety of a small molecule is inserted between a pair of base pairs, causing structural changes in the DNA and leading to its functional arrest.
Using this mechanism, a light-sensitive molecule is inserted into the cell surface of a neuron (usually through a virus vector).
Interestingly, Arg325 from a symmetry related molecule is inserted into the binding pocket, mimicking the methyl-lysine binding in L3MBTL2 [1].
At the coiled-coil interface, the a position knob from one molecule is inserted into a hole formed by four side chains at d-g-a-d positions of the neighboring molecule; and the d position knob is inserted into a hole formed by side chains at a-d-e-a positions of the neighbor.
Because we expect to observe full current blockage only when the molecule is inserted completely into the nanopore, this parameter is closely related to the pore length.
This is a concerted reaction between singlet oxygen and carbon-carbon double bond in which the oxygen molecule is inserted at either carbon atom of the C = C bond [ 33, 34].
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In both systems, the DOM molecule was inserted into one of the clay interlayers.
It is worth noting that a crystal structure of the synaptotagmin-1 C2B domain [43] concluded that one of the aspartate side chains (D371) does not coordinate directly the Ca2+ ion in site 2, since a water molecule was inserted between this Ca2+ ion and D371 (Figure 5C).
After transformation, the new gRNA target molecule was inserted between the promoter and gRNA scaffold.
The patulin molecule was inserted in the hydrophobic cavity that was formed by Ala291, Leu238, and Leu219.
The ciprofloxacin or moxifloxacin molecule was inserted into an implicit simplified bilayer using the IMPALA method described previously (18).
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