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Taken together, Chol-let-7a represents a potential useful modified molecule for systemic HCC therapy.
Chol-let-7a represents a potential useful modified molecule for systemic HCC therapy.
Given the observed high affinity of Chol-let-7a for liver tissue in nude mice, we hypothesize that Chol-let-7a may be an ideal modified molecule for systemic HCC therapy.
Because of the high affinity of Chol-let-7a for liver tissue in nude mice (data not shown) and the convenience of systemic administration, Chol-let-7a represents a potential useful modified molecule for systemic HCC therapy.
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Although many aspects of innate immunity are shared with higher vertebrates [4], nematodes lack a cell-mediated immune system and thus rely upon secreted antimicrobial molecules for a systemic immune response to pathogenic challenge [2].
See related research by Abdulahad et al., http://arthritis-research.com/content/14/4/R184 The recent report by Abdulahad and colleagues [ 1] that urinary HMGB1 may be a maker of lupus nephritis is the latest addition to a growing body of literature implicating a central role for this molecule in systemic lupus erythematosus (SLE).
Bioadhesive polymers in buccal drug delivery systems play an important role in delivery of therapeutic drug molecules for local and systemic action.
For systemic absorption, the intact drug molecules must traverse the impending harsh gastrointestinal environment.
Thus, formulations designed to release payload in the colon could be advantageous for systemic delivery of poorly permeable molecules.
Thus, developing specific small molecule TLR9 antagonists may represent a new approach as a preventive therapy for systemic lupus erythematosus.
As such, the potential for systemic absorption of a protein from the digestive tract as an intact molecule is very much less than that of low-molecular-weight chemicals.
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