Sentence examples for molecule for hydrolysis from inspiring English sources

These residues were chosen because they appeared ideally positioned to order a water molecule for hydrolysis.

In PhPncA, the function of the Zn2+ ion was suggested to be catalytic through the activation of a water molecule for hydrolysis of the thioester bond formed between the catalytic cysteine residue and the substrate in the acylenzyme intermediate.

The triad of Gα residues that mediates GTP hydrolysis includes Thr181 and Arg178 in switch I that stabilize the γ-phosphate ion and Gln204 in switch II which coordinates the critical nucleophilic water molecule responsible for hydrolysis of the γ-phosphate, is completely conserved (numbered as in human Gαi1, Figure 2) [26].

It was speculated that the hexyl tail of covalent-orlistat may pack against His and prevent the access and activation of a water molecule needed for hydrolysis of the covalent bond between orlistat and Ser.

Inspection of the crystal structure of the complex between the Rap1A and the Ras-binding domain of c-Raf1 shows that T35 helps in coordinating the gamma-phosphate of GTP and the attacking water molecule required for hydrolysis.

It is widely accepted that the open conformation of myosin, as exemplified by the S1dC·MgPPi or S1dC·MgATP complex (25, 41), is not competent to hydrolyze ATP because the water molecule responsible for hydrolysis is not in an appropriate location for nucleophilic in-line attack on the γ-phosphoryl moiety.

The second acidic residue, usually glutamate, primes a water molecule for the hydrolysis of ATP [24].

From biochemical and structural studies of colicin E9, His103 acts as the general base to deprotonate a water molecule for the hydrolysis of the scissile phosphodiester bond.

Consequently, it is feasible to assume that NLRs use diverse mechanisms to prime the water molecule for ATP hydrolysis, where one might be the replacement of one conserved acidic amino acid by utilizing what we propose to term: an extended Walker B box.

The conserved lysine in the Walker A motif participates in nucleotide binding and the conserved glutamate in the Walker B motif facilitates activation of a water molecule for the hydrolysis reaction [ 5].

The Mg2+-ATP binding induces a closing of switch 1, which drives the formation of several new interactions such as a salt-bridge between switch 1 and switch 2 that assists in stabilizing the β-phosphate and enables the coordination of the Mg2+-ion and proper positioning of the surrounding water molecules for ATP hydrolysis.