The carnosine 2 molecule defines a wide pore space, filled by eight H2O molecules per unit cell, and exhibits a conformation similar to those of the MeOH-containing structure, but with the amine group pointing in the opposite direction.
From these images, a set of label locations on each DNA molecule defined an individual single-molecule map.
A surface trench runs the length of the long edge of the molecule, defining a putative dsRNA-binding site.
The cupric centres in both units are bridged by two phenolate oxygen atoms from two deprotonated HSL molecules, defining a central Cu2O2 core.
Based on the results presented here, we propose that the inclusion of a PspA molecule, defined by its ability to induce cross-reactive antibodies against different PspAs, in the current DTPw vaccine, constitutes an efficient strategy for a new vaccine against pneumococcal infections, with broad-coverage and low-production cost, for vaccination of children in developing countries.
Small molecule (defined here as smaller than a molecular weight of 800 Da) binding to proteins has also been investigated extensively with HDX MS. The small molecules in question are often therapeutic drugs but can also be natural substrates, regulatory molecules, metal ions, or antibiotics.
The membrane molecule defined by monoclonal antibody CD64 is a high-affinity receptor (FcγRI) found on normal monocytes and only expressed at low levels by normal neutrophils.
All except one of the lines expressed the molecule defined by 5C11, the antibody specifically reactive with ES.
The main disease factors are the HLA-DQ molecule encoded by DQA1 and DQB1 genes and the HLA-DR molecule defined by DRB1 alleles [ 8– 12].
Gene expression refers to the level of production of protein molecules defined by a gene.
