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In the past, both, ligand and structure based methods intended to predict if a small molecule could cause fatal heart arrhythmias, "torsades de pointe" and sudden death.
Fullerenes (C60) can form aqueous suspended colloids (nC60); the question arises of whether a redox-active, lipophilic molecule could cause oxidative damage in an aquatic species.
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Whether ROS would serve as signaling molecules or could cause oxidative damage to the tissues depends on the delicate equilibrium between ROS productions, and their scavenging (Sharma et al. 2012).
ROS was generated from the interaction between radiation and water molecules, which could cause tissue injury.
As we could not revert the inhibition of MLR activity caused by RCC culture supernatants with either of the antiangiogenic compounds, we fractionated the RCC-10 supernatant to determine the molecules that could cause this effect.
Theoretically, every known odorant molecule could have an agreed descriptor.
Although only short fragments were hybridized, secondary structures formed either within one sample molecule or between different targets could cause inefficient binding to the array-bound probe molecules.
However, forming a complex with another catalytic strand poses a problem: Having too many G's on the 3′-end, which would, in principle, ensure a high complex formation probability, could cause a molecule to fold on itself (forming a stem), thus leaving no dangling ends.
CisPt resistance occurs because of the fact that not all CisPt molecules reach the nucleus where they could cause cellular death; they may instead bind to endogenous molecules present in the cytoplasm [ 16].
The electrostatic repulsion between negatively charged PnA molecules and negatively charged immobilized GM1 could cause a reduction in the adsoprtion rate of additional protein molecules binding to the surface as the PnA surface density increases with increasing bulk concentration.
This is likely a consequence of the PEG molecule's bulk and mobility which could cause periodic occlusion of the binding interface, slowing the on-rate of binding.
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CEO of Professional Science Editing for Scientists @ prosciediting.com