When only one drug molecule binds with one receptor, n = 1, and Eq. 3 can be simplified (Eq. 4).
Studies with gp120 allowed to determine the stoichiometry of the reaction between gp120 and CAP, resulting in the observation that approximately one CAP molecule binds to one molecule of gp120.
In the case of inhibitors such as ibuprofen and mefenamic acid, the first molecule binds to one subunit of COX-2 with high affinity.
After diffusing away from the cell that produced them, a secreted extracellular Bp (Bp out) molecule binds to one of the cells in the community irreversibly, and the protein is then converted into another transcriptional activator (Cp).
Let us consider adsorption of an oxygen molecule to a cus surface site, surrounded by oxygen atoms, as shown at the subimages α, β, and γ of Figure 2. Once it has approached the site, the O2 molecule binds by one of its atoms to the Ru atom corresponding to the site (configuration O2*), and it gains 0.78 (case α) or 0.58 eV (cases β, γ), compared with the energy in the gas phase.
One molecule of M6P/IGF-IIR binds one molecule of IGF-II and two molecules of M6P [69, 70].
One molecule of the flavonoid binds one molecule of the MtbHadAB hetero-dimer.
The orientation of TFs affects the affinity of the TF for a specific position on the DNA, i.e. a molecule bound in one orientation can have a totally different affinity compared with being bound in the opposite orientation at the same position.
Fluorescence emanating from such a molecule bound to one of these enzymes could turn that enzyme into a beacon letting medical practitioners and researchers figure out just where in the body S. aureus cells are holed up and helping them gauge the success of, say, antibiotic treatments.
Thus, a single indomethacin molecule bound in one subunit is sufficient to inhibit the oxygenation of either a fatty acid or fatty acid ester substrate in the other subunit.
