We designed and synthesized a novel mutual prodrug, named BC-01 (3), by integrating ubenimex and Fluorouracil (5-FU) into one molecule based on prior research results that showed that a combination of the aminopeptidase N (CD13) inhibitor, ubenimex, and the cytotoxic antitumor agent, 5-FU, exhibited improved in vitro and in vivo antitumor efficiency.
In each experiment, only ∼10% of the beads carried amplified a product given the low input ratio of DNA molecules to beads assuring that most of the beads get attached to only one initial molecule based on Poisson distribution.
This paper describes an aptamer-based optomagnetic biosensor for detection of a small molecule based on target binding-induced inhibition of magnetic nanoparticle (MNP) clustering.
Histamine is chemically classified as an amine, an organic molecule based on the structure of ammonia (NH3).
Red circle in molecule: based on the reaction SMARTS patterns, the corresponding reaction centers are labeled.
These surfaces are assigned to a molecule based on its functional groups and geometric properties.
An algorithm to identify functional groups in a molecule based on iterative marching through its atoms is described.
For instance, multiple redundant entries for a given molecule, based on database-specific indices may exist without explicit equivalence assertions.
Compound 8 was the first example of high ordered hexagonal columnar liquid crystalline molecule based on CTV skeleton.
First, our algorithm assigns a score to each atom and bond of a molecule based on the weights of the linear SVM model.
In this work, we synthesized a new donor molecule based on a combination of carbazole as a core-unit and rhodanine as an electron-withdrawing end-unit.
