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An in silico structure-based ligand design approach resulted in the identification of the first non-peptidic small molecule able to inhibit protein protein interactions between 14-3-3 14-3-3 14-3-3
A molecule able to recognize cardiomyocytes would have significant value in diagnosis and treatment.
MP0250 is a multi-DARPin trispecific molecule able to neutralize the activities of VEGF and hepatocyte growth factor (HGF) simultaneously.
A Morse manipulator like molecule able to modulate the electronic standing wave pattern of metallic Shockley surface states is presented.
Nitric oxide is currently used in medicine mediating vasodilation, and it has recently showed a great potential as a molecule able to dislodge biofilms (Wang et al. 2005; Barraud et al. 2006).
While further research is needed to define its function, our data indicate that MgC1q is a pattern recognition molecule able to recognize pathogens during innate immune responses in Myitilus galloprovincialis.
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siRNAs are very potent drug molecules, able to silence genes involved in pathologies development.
These cells secrete inflammatory molecules able to interact with proteins of ECM like collagens, laminins, elastin, and tenacins.
Bioscavengers are molecules able to neutralize neurotoxic organophosphorus compounds (OP) before they can reach their biological target.
The molecules able to satisfy the pharmacophore have been submitted to a docking phase to filter molecules with a high propensity to interact with HDAC7 enzyme.
Inhibitory strategies have focused on antisense molecules, inhibitors of reverse transcriptases, and small molecules able to interact with and stabilise four-stranded (G-quadruplex) structures formed by telomeres.
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