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Moisture contamination must be below 0.02% to prevent molecular weight reduction by hydrolysis (Scheirs 1998).
However, the molecular weight reduction caused by hydrolysis was less than 5%.
The total molecular weight reduction was around 18%, combined with the melt extrusion and injection molding processes.
For sufficiently long polymerization times, chain scission and molecular weight reduction occurred via hydrolysis of the amide linkages.
The molecular weight reduction as a function of applied shear stress as deduced from the model agrees satisfactorily with the results from experimentally obtained engineering scale data.
The cross-linking of PCL which occurred due to BCY transesterification compensated for molecular weight reduction of the polymer under melt spinning conditions.
Similar(43)
Molecular weight reductions during the second pass increased with increasing specific mechanical energy, and were less drastic than the initial drop.
The hydrolytic process employed for EM production was effective in the weight-average molecular weight (MW) reduction, as confirmed by data on EM hydrolysis degree (DH) and MW.
Under these conditions, the extent of β-scission (a radical chemistry that results in cleavage of C C backbone bonds) is significant; thus, the product of functionalization by reactive extrusion suffers dramatic molecular weight (MW) reduction and degradation of properties.
We also demonstrated that besides enhancing chromatography separation and improve product quality, especially for high molecular weight (HMW) aggregate reduction, mixed-mode resins can also help to improve process efficiency in industrial-scale mAb drug manufacturing.
This unique post treatment demonstrates two and half fold increase of molecular weight and significant reduction of band gap (1.8 1.5 eV); the pre-functionalized value is above 2 eV.
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