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The selective T1 experiment will resolve the molecular weight problem; however, the WaterLOGSY and selective T1 experiments are both rather qualitative in estimating the existence of the oligomerization and aggregation states.
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Also the molecular weight is not the problem.
High molecular weight of cerium oxides poses problem in the flow of solids in the process.
To circumvent this problem, low molecular weight additives, called cosolutes, have been developed, including cyclodextrins [ 96, 97].
The ultra-high molecular weight of sepiolite/nanocomposites introduces significant problems with processability.
The fact that the kinetics is a lot more complicated than that of ordinary polymerization systems makes the problem of controlling molecular weight a difficult one.
For instance, it is possible that some glycolytic enzymes were not considered in this analysis because of the pI or the molecular weight ranges employed, comigration phenomena and problems of saturation staining.
C1q is a basic high molecular weight glycoprotein which has two major problems in its purification: a low yield and contaminant inmunoglobulins [ 26], and because of its low yield, it was necessary to concentrate samples for SDS-PAGE analysis with Strataclean beads (Stratagene).
Potential problems were encountered as low molecular weight restriction fragments i.e. <50 bp were found to be less detectable and spurious bands were apparent.
As HTS has gained popularity, drug candidates have had increasingly higher molecular weight and lipophilicity, leading to lower solubility which is considered the predominant problem [5].
To alleviate the matching problems between the layer permeability and the injected polymer molecular weight, a molecular weight adjusting device with porous medium was designed on the basis of mechanical degradation principle.
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