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The high molecular weight polymer (Mn = 11800) could be obtained.
However, microspheres fabricated with high molecular weight polymer had expression for only 14 days.
The plasticizer may be a low molecular weight solvent, or be a low molecular weight polymer.
Both high molecular weight polymer ICs were successfully made by ultrasonic and heating techniques.
OTU 6 and 7 were also typical for mesh samples (26.2%, 22.8% and belonged to the Bacteroidetes family, which is linked with high molecular weight polymer degradation rather than monomers (Cottrell and Kirchman, 2000; Fernández-Gómez et al., 2013).
Conjugation of a drug to a high molecular weight polymer chain improves pharmacokinetics while retaining the drug potency.
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This may be attributed to the high spinning stress generated by the high-molecular weight polymer used.
It has been suggested that low-molecular weight polymer chains migrate to the surface to cover up the thermodynamically unstable hydrophilic surface [26].
The third phase is fragmentation of the polymer into segments of low-molecular weight polymer resulting in loss of mass.
Both high-molecular-weight polymer ICs were successfully made by a heating technique.
The synthesized drug carrier demonstrated much better sustained drug release profiles for ibuprofen of 5 days (low-molecular-weight polymer) and 9 days (high-molecular-weight polymer) compared with 30 min of pure TiO2 nanotubes.
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