Lowering molecular weight including the use of conformational constraint led to compounds with less CYP 3A4 liability compared to early leads.
YjiC conjugates different sugar units in plant natural products with low molecular weight, including chalcone (Pandey et al. [2013a]), flavonols (Pandey et al. [2013b]) and potential anticancer drugs such as geldamycin (Wu et al. [2012]).
The Endo-M-N175Q mutant has recently been shown to act on proteins with a broad range of molecular weight including IgG (Fig. 5) despite a preference of low molecular weight proteins as acceptors.
As increase of rotational speed from 0 to 400 rpm, the molecular weight including Mn and Mw decreases from 67,100 to 26,000 and 70,000 to 43,000, respectively.
High resolution gel permeation chromatography showed that the compositions of the copolymers were complex, consisting of higher molecular weight coupled products, and products of lower molecular weight including, probably, homo-PS.
The xylanases of C. flavigena correspond to this regularity: the products of xylan hydrolysis by CFXyl1 and CFXyl2 were of low molecular weight, including xylose, while the CFXyl3 formed very small amounts of xylose In contrast to majority of GH10 family members, CFXyl4 xylanase, like GH11 xylanases, produced very small amounts of xylose.
Minimum molecular weight included in the distribution.
The general form of this function is shown in Eq. (9) in which, β is skewness of exponential distribution function, M is molecular weight and τ is the minimum molecular weight included in the distribution.
The MoS2/TiO2/SiNW substrate has shown high performance for the detection of small compounds of different molecular weights, including glutathione, glucose, amino acids, antibiotics to name a few.
Also, pTyr-proteins with more varied molecular weights, including lower molecular weights, were detected in malignant tissues.
In renaturation assays, TNF-alpha induced a rapid activation of different protein kinases of different molecular weights, including the 50 kDa protein kinase (PK50) followed by the 35 kDa protein kinase (PK35), in the parental Kasumi-1 cells.
