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A hydrolysis study of the uncrosslinked polymers at physiological temperature showed between a 19.8% and 28.8% mass loss and between a 80.4% and 98.9% molecular weight decline after 12 weeks.
As may be expected, the ethyl glycinato substituted phosphazene (PNEAEG) had the fastest molecular weight decline, whereas the biphenyl substituted phosphazene (PNEAPhPh) had the slowest molecular weight decline.
PNEAPhPh, on the other hand, did not experience as great of a molecular weight decline as the other two implants and had a molecular weight decline of only 63% after 12 weeks.
The mass loss after 30 days was approximately 60% and the molecular weight decline was slightly less than 40%.
This showed that as the hydrophobicity of the ester group increased (from methyl to benzyl), the molecular weight decline of the polymer decreased.
In this systematic study, the molecular weight decline was in the order of PNBzG < PNtBG < PNEG < PNMG, with PNMG having the greatest decrease in molecular weight.
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For 100 kDa molecular weight cutoff membranes, flux decline was more severe.
However, excessive CFAL beyond the optimized dose inhibited M.A. removal due to hydrolysis and declining molecular weight of chitosan that weakened the bridging netting properties, where surface charge reversal happened within a narrow dosage range and the removal dosage curve became parabolic.
Processes such as extrusion and hot drawing contributed to the decline in molecular weight of a material.
In vivo degradation studies showed substantial decline in molecular weight for the PNEA and PNEAmPh implants after 12 weeks, 80%and98%8%, respectively [ 47].
However, PLGA in PLGA-doped PHT (A) fibers demonstrated significant decline in molecular weight of 11.6% after eight weeks which was significantly lesser as compared to PLGA (R) and PLGA of PLGA-undoped PHT (R) samples at eight weeks (P < 0.05).
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