Sentence examples for molecular weight agents from inspiring English sources
The reviewed findings provide a proof of principle that targeting of critical repetitive sequences (not necessarily coding regions), which allow for clustering of drug binding motif, can be the paradigm for region specificity of small molecular weight agents.
Intratumoral infusions were anisotropic and resulted in limited coverage of the enhancing tumor area and adjacent peritumoral regions.CED has the potential to deliver high molecular weight agents into tumor-infiltrated brain parenchyma with volumes of distribution that are clinically relevant.
For example, their susceptibility to digestion with subtilisin [1], their velocity and extent of reactivation from guanidine chloride unfolded monomers [2], and their susceptibility to inactivation by several low molecular weight agents [3].
High molecular weight agents are mainly absorbed through lymph nodes, whereas low molecular weight agents are mainly absorbed through vessels [ 30].
Small molecular weight agents readily leak from the vasculature and distribute within the tissue according to a concentration gradient.
Although atopy is considered a risk factor for occupational asthma due to high molecular weight agents, most studies are workforce based and lack statistical power to study effect modification in sufficient detail.
The absorption rate of IHL-305, a high molecular weight agent, has been shown to be lower than that of CPT-11.
The use of monoclonal antibodies alone may lead to heterogeneous uptake within the tumour tissue; the use of a second, low molecular weight agent may provide greater penetration into tumour tissue.
Our results are of relevance for all hypoxia-PET tracers and any tumour site where transport of small-molecular weight agents is challenged.
In asthma due to low-molecular weight agents (e.g. isocyanates, anhydrides), an IgE or IgG-mediated response may be involved [ 11].
An allergic immune response generally involved if the exposure constitutes of a high-molecular weight agent (e.g. latex, enzymes, animal dander) [ 10].
