Use of molecular data to study evolution and ecology; currently, the research is devoted to exploring ways of combining information from surveys of molecular variation with data on demography and current historical distributions in order to infer population processes in space and time.
We examined the patterns of Cytb molecular variation with the methods of prediction of the secondary structure of nucleic acids and used the data on the fishes' life history.
Although microarray studies of prostate cancer have already identified the different gene expressions between normal and cancer, they still use the traditional unsupervised clustering methods to realize the potential molecular variation with individual genes.
To address this issue, we have analyzed the mitochondrial DNA (mtDNA) of 185 individuals and NRY (non-recombining region of Y chromosome) of 98 individuals belonging to two major tribal populations of Maharashtra, and compared their molecular variations with that of 54 South Asian contemporary populations of adjacent states.
Considering challenge on phenotypic and genotypic patterns of L. tropica in suspected patients in Khuzestan was that L. tropica had no polymorphic amastigotes but have more molecular variations with many differentiations in nucleotides of each sequences (haplotype) [ 10, 17].
Being a heterogeneous disease, AML has been the subject of numerous studies that focus on unraveling the clinical, cellular and molecular variations with the aim to better understand and treat the disease.
We initially examined the bovine orthologs of genes implicated in human disease for molecular variation associated with the osteopetrosis phenotype.
We therefore refined our examination of wBol1 to look for fine scale molecular variation associated with more variable phage insertion loci, as found in detailed studies of Wolbachia variation in Drosophila and Culex [ 19, 33, 34].
In an effort to identify molecular variation associated with osteopetrosis, we amplified and resequenced each candidate gene from DNA samples from normal, carrier and affected individuals, and subsequently compared the sequences of affected calves with the others.
In total, just under 20% of all the NBS-encoding genes had patterns of molecular variation consistent with the action of selection, as measured by skewed diversity (θπ and θw), allele frequency spectra (Tajima's D) and between group differentiation (FST) values.
By analyzing the patterns of genetic diversity in this framework, we identify the molecular signatures during the replacement and compare these with those observed in sequences of influenza A. Understanding molecular variation in populations with a complex demographic history is of utmost importance [1], [2].
