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Conclusion: The decreased number of GC receptor and the molecular variation of GR on mononuclear cells could explain the phenomenon of GC resistance, potentially to endogenous GC, which suggested an etiological significance of neuro endocrine immune mechanism in lupus nephritis.
The complex epidemiology of CA is related to the genetic characteristics and mechanisms of molecular variation of the Mycoplasma spp. involved, along with presence of CA-mycoplasmas in wild ruminant species.
The molecular variation of paired domain box gene 9 (PAX9) was previously investigated by our research group and a high degree of evolutionary conservation in coding and non-coding regions was observed except in exon 3. PAX9 is a transcription factor important in tooth development, and we wanted to verify its role in dental agenesis in detail.
We then analyzed the DNA molecular variation of HLA at several geographic scales (i.e. worldwide, continental, and regional) to investigate its congruence with the observed genetic diversity profiles based on allelic frequencies and explore the additional information brought by DNA sequences.
The three first principal coordinates of the PCoA explained 44.77% of the total molecular variation of the ITS clones.
Molecular variation of the strepsirrhine V1R I subfamily has been explored using a traditional Sanger sequencing of cloned inserts approach [ 29].
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Contrasting patterns of molecular variation between areas of allopatry and sympatry is pivotal in excluding ancestral polymorphism as an explanation for the observed allele sharing and gene paraphyly between co-occurring species of Iberian Barbus and Luciobarbus.
Phenotypic divergence did not increase with geographical location, and population age did not make a significant contribution to the extent of molecular variation in any of the two trout species.
Study of the adaptive maintenance of molecular variation historically has followed one of two approaches, elucidation of the functional components of molecular adaptations at the biochemical level, or description of the historical footprints of selection acting on sequence variants [3].
Analyses of molecular variation support the separation of all coastal wolves in a group divergent from continental populations, as predicted based on hypothesized subspecies designations.
The authors provide rich detail of molecular variation within and between populations of these species and describe how patterns of population genetic variation have contributed to our understanding of the evolution of virulence and virulence factors in these pathogens.
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