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Objective: The object of this study was to assess the association of histologic, cytokinetic, and molecular variables in preoperative endometrial samples with extrauterine disease, recurrence, and survival among patients with endometrial cancer.
However, the patterns associated with known molecular variables in HaCaT cells cluster separately from the CoGAPS estimated patterns.
We performed unsupervised clustering of carcinoma cases according to their protein expression profiles, and we tested distribution of categories of clinical and molecular variables in these groups.
Oncotype assays by RT-PCR of the 16 molecular variables in other patient cohorts are reportedly associated with AUCROCs in the same range.
An important role of molecular variables in defing relapse of breast cancer after local and systemic therapy has been raised during the past decade.
Furthermore, neoadjuvant chemotherapy represents an opportunity to correlate molecular variables in the initial biopsy with treatment response and to explore mechanisms of drug resistance.
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With the aim of identifying molecular variables useful in tumor subtypes discrimination, comparisons of each variable were made between TC vs. AC and LCNECs vs. SCLCs.
Conclusions: Preoperative evaluation of quantifiable cytokinetic and molecular variables can assist in identifying tumor types that are predisposed toward a more aggressive clinical course.
Statistical analysis was performed in order to ascertain which clinical and molecular variables may influence outcome, in terms of disease-free survival (DFS) and overall survival (OS).
A case-cohort study was designed to correlate various histopathologic and molecular variables with distant failure in endometrial cancer by analyzing phenotypic and molecular indices in hysterectomy specimens.
The molecular variables studied were estimated in relation to the patients' age.
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