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Nuclear pore complexes (NPCs) mediate molecular trafficking between nucleus and cytoplasm [1], [2].
The BBB is responsible for the proper functioning and homeostasis of the central nervous system (CNS) by regulating cellular and molecular trafficking between blood and brain parenchyma.
Upon initiation of inflammation, cellular and molecular trafficking between the periphery and the draining LNs through the expanded lymphatic vascular network significantly influences the progression of the inflammatory response by modulating the degree of tissue infiltration and shaping the immune response [ 3– 5].
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First, mirror-enhanced dSTORM is demonstrated for the nuclear pore complex (NPC), which plays a key role in the regulation of molecular traffic between the cytoplasm and the nucleus17.
The brain endothelium forms the blood brain barrier (BBB) and is the chief site regulating molecular traffic between blood and brain.
The molecular traffic between the cytoplasm and nucleus is essentially controlled by nuclear pore complexes large, multi-protein structures that are embedded in the membrane.
Direct contact between uncalcified cartilage and lamellar bone also allows opportunities for molecular trafficking and/or the transmission of physical forces.
Turgeon, R. & Wolf, S. Phloem transport: cellular pathways and molecular trafficking.
The interface between CNS and the peripheral circulatory system functions as a dynamic regulator of ion balance, a nutrient transport, and molecular trafficking is historically known as blood-brain barrier (BBB) [ 1].
BBB forms a barrier because tight junctions between adjacent endothelial cells force most molecular traffic to occur across the BBB through the cells [ 17].
This coupling function requires the regulation of molecular traffic through the gaps.
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