It's that important". Discovered in 1984, kinesin is now recognized as the workhorse of the cell, hauling chromosomes, neurotransmitters and other vital cargo along tiny molecular tracks called "microtubules". Many types of kinesin and kinesin-related proteins have been discovered in the past two decades in a wide range of organisms -- from yeast to humans.
Kif1C operates inside the cell like a freight train, carrying cargo along molecular tracks called microtubules.
Sahl, S. J., Leutenegger, M., Hilbert, M., Hell, S. W. & Eggeling, C. Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids.
We demonstrate that Gamillus can serve as a molecular tag suitable for imaging in acidic organelles through autophagy-mediated molecular tracking to lysosomes.
Carbon dots exhibit great potential in applications such as molecular imaging and in vivo molecular tracking.
Independent methods, such as EM analysis of DNA-unwinding intermediates forming ssDNA loop-tail prior to Chi [44], [45] and the optical trap method of single molecular tracking of ssDNA-RecBCD complex [46], have confirmed that the translocation activity of the two motors are 'uncoupled' to each other before encountering Chi.
To our best knowledge, this is the first demonstration of dynamic molecular tracking entirely within the cell environment.
This system marks the first example of a large-amplitude, well-defined, controlled switching of the position of a component along a molecular track.
However, using molecular tracking, we have shown prospectively that etoposide-induced MLL cleavage preceded MLL rearrangement by 3 months, and furthermore, using the panhandle PCR method, that MLL rearrangement could only be detected at the diagnosis of t-AML.
By molecular tracking, we were able to show that MLL cleavage preceded gene rearrangement by 3 months and before the clinical diagnosis of t-AML in a patient with haemophagocytic lymphohistiocytosis.
It is thought that AChRs diffusing freely on the muscle surface become clustered at traps generated by synaptogenic stimuli at the NMJ [15]; this diffusion-mediated trapping of AChRs has recently been directly visualized through single-molecular tracking with quantum dots [16], [17].
