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The principle of molecular tests is the demonstration of the occurrence of sequences of nucleotides, which are specific for a trypanosome subgenus, species or even type or strain.
Further validation of markers and development of molecular tests is indispensable for the reliable up- or down-staging of LNs.
23 The commencement of such decolonisation regimens prior to surgical procedures, which can be facilitated by rapid detection of S aureus carriage with molecular tests, is likely a key factor in the success of this approach.
INH has a more complex mode of action and resistance occurs through several discrete mechanisms involving many genes, therefore detection of INH resistance through molecular tests is less reliable than RIF [ 9, 10].
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Molecular tests are available only for first-line antituberculosis drugs.
When the molecular tests were performed, by entomologists at Penn State, they con-firmed van Engelsdorp's initial impression.
Molecular tests are being developed for bladder cancer and colon cancer, for example, that would look for individual genes that go awry, long before any tumors are evident.
Many of the new molecular tests are quick but technically demanding, and each laboratory may do them in its own way.
Novel molecular tests are gaining popularity as a rapid way to detect genetic mutations that render tuberculosis impervious to drugs.
"Looking forward," said Dr. Wright of Columbia, "the molecular tests are becoming so good that we can see a time when cytology is no longer used as the primary screening test".
Thus, our results comply with the WHO's recommendation of rapid DST of M. tuberculosis in settings where molecular tests are unavailable.
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