It is possible to describe bacterial diversity in real environment by combining molecular biology technology based on 16S rRNA gene analysis and culture-dependent approaches as there have been a number of advances in microbial ecology.
Previous studies in our laboratory and others have demonstrated the superior sensitivity and accuracy of molecular biological technology, based on the DNA amplification technique of polymerase chain reaction (PCR); [5],[6]) and for the detection of infection in symptomatic arthroplasty patients (Mariani et al. 1996b; [7]–[1996b
A new molecular marker technology, based on genome sequence and physical map locations, is reported for those species whose assembled genome sequences are available.
To identify the critical structural determinants on tau responsible for pathological tau tau interaction, we developed molecular imprinting technology based on the unique properties of mAbs recognizing structural changes of naturally disordered proteins.
Molecular marker technologies, however, are currently undergoing a transition from largely serial technologies based on separating DNA fragments according to their size (SSR, AFLP), to highly parallel, hybridization-based technologies that can simultaneously assay hundreds to tens of thousands of markers (e.g., Single Nucleotide Polymorphisms or SNPs) [ 12].
Recently, an inverse virtual screening (IVS) technology based on molecular docking methods has been developed and widely used for the process of target identification (Chen and Zhi 2001).
We use the SAP (spatial-aggregation-propensity) technology based on molecular simulations to determine the aggregation-prone motifs in the constant regions of IgG1 classes of antibodies.
Molecular Electronics Inc., a start-up company based in Houston that is one of the first efforts to commercialize a new technology based on molecular-scale electronic circuits, has signed a confidential product development agreement with the Amphenol Corporation.
Optical molecular imaging technology is an emerging technology, based on genomics, proteomics, and modern optical technology.
