Sentence examples for molecular targets defined from inspiring English sources

With our increasing understanding of the genes and pathways that drive CRPC, therapeutic agents can be developed that act on the molecular targets defined by the key genetic and molecular abnormalities responsible.

These convergent mechanisms furnish investigators with some preliminary molecular targets for defining the OP proteome (the complement of proteins found in cells, tissues, or organisms that react with OP compounds) because the overall mechanism of organophosphorylation is most likely conserved for most other proteins (e.g., receptors, enzymes).

These observations emphasize the need to proceed to a multiparametric evaluation of several biologically linked molecular targets, to possibly define clusters of patients with a more aggressive tumour 'molecular profile'.

Picking targets, defining enemies.

Advances in deciphering the molecular mechanisms underlying mCRC have led to the development of novel agents that selectively inhibit defined molecular targets.

Nucleic acid aptamers are reagents selected in vitro from degenerate sequence libraries by their ability to bind to defined molecular targets.

The investigation of gene signatures may become more important in the future as an increasing proportion of agents under development for breast cancer treatment have defined molecular targets.

Besides apoptosis induction non-apoptotic functions of caspase-8 have been discussed, although these non-apoptotic signaling pathways and molecular targets have not been defined yet [ 25].

This crucial advance, pioneered by Thierry Boon and co-workers (van der Bruggen et al, 2002), has resulted in the development of vaccines based upon defined molecular targets.

Owing to the lack of defined molecular targets for TNBCs and due to the high proliferative rate of TNBCs and luminal B tumors, chemotherapy remains a first-choice therapeutic option for these two subtypes.

Molecular targeting therapy against defined signaling pathways has recently attracted much attention.