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This molecular switch decision for IL-2 expression per cell is located downstream of the cytosolic Ca2+ level.
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The molecular mechanism responsible for the lysogeny/lysis decision is known as λ switch [36].
Collectively, our data reveal that cIAP2 may work as a molecular switch for the decision between pro-inflammatory activation and apoptosis in microglia.
Based on the findings of the resent study, we have proposed a model to explain the molecular switch, which regulates the decision of p53 to activate BAX or NOS3 promoter (Fig 11).
It is currently unclear which molecular switch mechanism controls the decision of whether apoptosis or necroptosis is executed, but first reports from TAK1-deficient cells suggest a critical importance of this kinase and its co-factors.
In summary, the C/EBPβΔuORF mouse comprises the first genetic animal model that confirms the physiological significance of uORF translation in vivo and its action as a molecular switch driving cell fate decisions by modulating isoform expression ratios.
In light of this functional analogy between c-Abl and p53, it is possible that c-Abl could also act in the form of a molecular switch, mediating cell-fate decisions and inducing a shift from prosurvival to pro-death mechanisms under the appropriate circumstances.
This has led us to the hypothesis that BMP4 may be a molecular switch participating in the pathway decision that determines which form of late AMD develops.
This translation of a graded TCR signal into the observed binary decision process requires a molecular switch in the signaling cascade regulating the expression of IL-2.
Watch IBM's molecular switch in action.
A crucial component of the chip is its molecular switch, designed by Dr. Stoddart.
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