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Los, M. et al. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
It has been proposed that the TYMV TLS acts as a molecular switch between translation and replication.
Los M, Mozoluk M, Ferrari D, Stepczynska A, Stroh C, Renz A et al. Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.
Similar to most GTPases, Rac1 functions as a molecular switch between GTP and GDP and is regulated by numerous guanine nucleotide exchange factors (GEFs) and several GTPase-activating proteins (GAPs 29,30,31.
These structural features of cMyBP-C could facilitate its putative role as a molecular switch between actin and myosin and may contribute to modulating the transverse pliancy of the C-zone of the A-band across muscle sarcomeres.
gcm therefore acts as a molecular switch between the neuronal and glial cell fates.
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MyoD-centered transcriptional regulation via molecular switching between repressors and activators is well studied during myoblast differentiation.
The molecular switches between these opposite responses involve a complex array of signals and adaptive pathways determining whether the cell will survive or die.
The PI3K/Akt/mTOR pathway is well known as one of the key molecular switches between apoptosis and autophagy (Moretti et al, 2007; Wyllie, 2010; Li et al, 2011).
We provide evidence that in the context of renal injury, primary cilia act as molecular switches between canonical and non-canonical Wnt signaling activity, possibly determining between regenerative and pro-fibrotic effects of Wnt re-expression in the injured kidney.
Primary cilia are increasingly being recognized as cellular 'antennae' which sense and transduce signals from the microenvironment, particularly through Wnt and Sonic hedgehog signaling, and based on previous studies in Xenopus and zebrafish, it has been speculated that cilia can function as molecular switches between canonical and non-canonical signaling pathways [ 34, 35].
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