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Like nearly all GTPases, ARF6 functions as a molecular switch alternating between GTP-bound (active) and GDP bound (inactive) states.
Like all members of the Rho family, Rho1 functions primarily as a molecular switch, alternating between an inactive, GDP-bound state and an active, GTP-bound form (reviewed in [1]).
The ROC domain comprising of conserved motifs for GTPase activity is known to regulate kinase activity by acting as a molecular switch, alternating between GDP- and GTP-bound states [ 22, 26].
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Ras proteins are small GTPases that function as molecular switches, alternating between inactive (GDP-bound) and active (GTP-bound) states.
In most cases, members of the Ras superfamily act as molecular switches alternating between active, GTP-bound, and inactive, GDP-bound, conformational states.
Rabs function as molecular switches that alternate between two conformational states: the activated GTP-bound form and the GDP-bound inactive form.
These proteins belong to a larger Ras-related GTPase protein superfamily whose members function as molecular switches that alternate between inactive (GDP-bound) and active (GTP-bound) conformations.
These GTPases function as molecular switches in the cell by alternating between active GTP-bound and inactive GDP-bound states, mediated by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), respectively [1] [4].
He and his collaborators throw molecular switches together onto a small wafer with small gold particles.
A major challenge is to figure out how to address the individual molecular switches, Mr. Ellenbogen said.
The clinic says it uses "antineoplastons" – "molecular switches that turn off life processes in abnormal cells" – to treat cancer patients.
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