Sentence examples for molecular surrogates from inspiring English sources

Age-grading methods that delineate chronological age, using accurate molecular surrogates based upon gene expression profiles, will allow quantification of the longevity-reducing effects of vector control tools aimed at the adult, female mosquito.

Instead of having to rely on molecular surrogates with a limited resolution, such an approach would be highly informative both by giving a more accurate picture of ongoing tuberculosis transmission and related epidemiological outcomes such as re-infection and mixed infections, as well as by shedding light on the microevolutionary processes occurring in M. tuberculosis during spread.

These results drive the design of more effective COEs that will serve as an exact molecular surrogate for outer membrane cytochromes.

None of the other epidemiological studies report on specific fatty acids and the risk of molecular surrogate end-points for colon or rectal cancer or adenomas [ 35– 435.

The absolute requirement for TRPV1 for NGF-dependent heat hyperalgesia and nociceptor sensitization has led many workers to use increased TRPV1 activity as a molecular surrogate for sensitization.

To this end, we assessed if detection of global reduction of H3K27me3 by immunohistochemical staining could be used as a molecular surrogate for H3F3A K27mutationsns.

These results suggest that the phylogenetic analysis based on the VP4 nucleotide sequences is also useful as a molecular surrogate for antigenic HEV serotyping.

DOI: http://dx.doi.org/10.7554/eLife.00070.019 Using FLAG-H2BE as a molecular surrogate for H2BE, we examined the histone variant's localization on genomic DNA.

Oberste et al. have shown that HEV VP1 nucleotide sequences correlate with antigenically defined serotypes and have demonstrated the utility of VP1 sequences as a molecular surrogate for antigenic type (19, 35 ).

Our data give evidence for early categorical CTC-count enumeration, but not for continuous CTC-values, as a predictive molecular surrogate marker for treatment response in mCRPC patients up to 3.7 months before the first radiographic evaluation.

Thus far, no target marker has been identified that may predict PEP005 activity in colon cancer cell lines, thus warranting further preclinical research aimed toward detecting molecular surrogate markers of sensitivity to PEP005.