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Although IBC, like non-IBC breast cancers, is a heterogeneous disease and can occur as any of the five molecular subtypes, they are most commonly either ErbB2 overexpressing or triple negative [ 8].
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Approximately 70-75% of TNBCs share similarities with the basal-like breast cancer (BLBC) molecular subtype; therefore they have been considered erroneously as synonyms [ 9].
In this case, using constructed molecular subtypes, in addition to grade, they were able to classify patients based on rates of local-regional control.
Molecular subtypes have a clinical relevance inasmuch as they have different propensities to metastasize.
The cases of HER2 over-expressing intrinsic type, they were divided into molecular subtypes II and III.
The signatures were also significant when lymph node status was included and when stratifying for molecular subtype, indicating that they are independent prognostic markers.
We found that 55 out of 2,658 (2.1 %) tumors that are ERα positive by mRNA analysis also demonstrate a Basal molecular subtype, indicating that they lack expression of estrogen-responsive genes.
They were not included in following statistical analyses for characterization of the molecular subtypes.
However, they also displayed up to 11% nucleotide divergence from HTLV-1 strains from other molecular subtypes.
Their overlap/similarities allow the definition of molecular subtypes.
Recently, comprehensive genomic studies defined three distinct molecular subtypes (TYR, MYC and SHH) of ATRT.
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